Although not available in the United States, Valdoxan (agomelatine) is the first ever melatonergic antidepressant in that the drug activates specific melatonin receptors (MT-1, MT-2) in the brain. Valdoxan claims to improve sleep disruption without affecting daytime vigilance by exerting specific actions on the regulation of circadian rhythms. The recommended starting dose is 25mg, once [...]
Q. Why do so many antidepressants seem to cause sexual dysfunction? A. In addition to its antidepressant effects, serotonin is a rather powerful vasoconstrictor. It can restrict blood flow to sexual organs and negatively impact sexual performance, libido and the ability to reach orgasm. Q. Is Prozac’s long half-life a drawback to its action? A. [...]
- All antidepressants, irrespective of category or class, have similar efficacy, however most of them have different side effects. With antidepressants, no one-size-fits-all, therefore it makes sense for many clients to choose their own initial antidepressant based on what side effects they are willing to tolerate. – Fifty percent of depressed patients respond to antidepressants; [...]
1. First and foremost, you should know that depression is a real illness, not a character flaw or a weakness. In this regard, it is no different from diabetes or hypertension, and it is highly responsive to appropriate treatment, which may include more than just medication alone. 2. You should know what to expect from [...]
I suppose the answer to this question hinges on the definition of deliver. Let’s start up top with the bottom line: Treating depression pharmacologically is not easy! A major study, the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) is the largest independently funded clinical trial for depression. The study’s primary objective was to develop a [...]
Escitalopram (Lexapro), has gained FDA approval for the acute and maintenance treatment of major depressive disorder (MDD) in adolescents ages 12 to 17 years. “Adolescent depression can often be challenging to treat because there are limited treatment options that are proven to be effective and well tolerated in this patient population,” noted Graham Emslie, MD, [...]