Augmenting Antidepressants with Deplin (l-methylfolate)

Vitamin B folate or folic acid — active in citrus fruits, legumes, green, leafy vegetables — is yet another arrow in the psychiatrist’s quiver for managing treatment – resistant depression (TRD).

Deplin (l-methylfolate) is a folic acid type of derivative. Deplin helps normalize amounts of the neurotransmitters norepinephrine, serotonin and dopamine when used in conjunction with antidepressants. Folate is also crucial to the production of S-Adenosyl-Methionine, or SAM-e, which aids in the synthesis of nerve cell membranes and activates norepinephrine, serotonin and dopamine – three neurotransmitters linked to depression. Numerous studies have found that depressed patients consistently have lower serum folate concentrations.

Joseph Wegmann, R.Ph., LCSW is a licensed clinical pharmacist and a clinical social worker with more than thirty years of experience in the field of psychopharmacology. His diverse professional background in psychopharmacology and counseling affords him a unique perspective on medication management issues. In addition to consulting with numerous psychiatric facilities, he has presented psychopharmacology seminars to thousands of clinicians in 46 states.

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